3P279 Can new-folds emerge by protein module shuffling? : Computer experiment(Proteins- protein engineering, and evolutionary engineering,Poster Presentations)
نویسندگان
چکیده
منابع مشابه
Protein Structure: Evolutionary Bridges to New Folds
The question of whether novel, structurally different protein folds might have arisen from existing ones is crucial to understanding protein evolution. Recent work on cysteine-rich domains in Hydra proteins illuminates how evolutionary transitions between dramatically different structures might occur.
متن کاملProtein folding and binding can emerge as evolutionary spandrels through structural coupling.
Binding interactions between proteins and other molecules mediate numerous cellular processes, including metabolism, signaling, and gene regulation. These interactions often evolve in response to changes in the protein's chemical or physical environment (such as the addition of an antibiotic). Several recent studies have shown the importance of folding stability in constraining protein evolutio...
متن کاملProtein folds and protein folding.
The classification of protein folds is necessarily based on the structural elements that distinguish domains. Classification of protein domains consists of two problems: the partition of structures into domains and the classification of domains into sets of similar structures (or folds). Although similar topologies may arise by convergent evolution, the similarity of their respective folding pa...
متن کاملEvolutionary approaches to protein engineering.
1 Targets and Tasks for Protein Engineering . . . . . . . . . . . . . . . . . . 56 1.1 Folding . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . 56 1.1.1 Thermodynamic Stability . . . . . . . . . . . . . . . . . . . . . . . . . 57 1.1.2 Thermal and Environmental Stability . . . . . . . . . . . . . . . . . . . . 57 1.1.3 Other Folding Considerations . . . . . . . . . . . . . . . . . ...
متن کاملProtein folds and functions.
BACKGROUND The recent rapid increase in the number of available three-dimensional protein structures has further highlighted the necessity to understand the relationship between biological function and structure. Using structural classification schemes such as SCOP, CATH and DALI, it is now possible to explore global relationships between protein fold and function, something which was previousl...
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ژورنال
عنوان ژورنال: Seibutsu Butsuri
سال: 2007
ISSN: 0582-4052,1347-4219
DOI: 10.2142/biophys.47.s272_4